An ancient retrotransposon provides species-specific tuning of IL-18 inflammatory signaling
Andrea D. Ordonez, Holly L. Allen, Lynn Sanford, Atma M. Ivancevic, Ashley Agyepong, Mia Chaw, James P. Bridges, Tony Schountz, Edward B. Chuong
The paper identifies an ancient retrotransposon-derived IL18R1-Short isoform that modulates IL-18 signaling across species.
bioRxiv · May 26, 2026 · PreprintEvolutionary Biology