Edward B. Chuong

This study determines cryo-EM structures of MeCP2 bound to nucleosomes and identifies how RTT mutations affect nucleosome interactions and chromatin targeting.

The paper shows how epigenetic coalitions in birds couple tissue growth to generate periodic color patterns through ASIP regulation and feedback loops.

The paper identifies an ancient retrotransposon-derived IL18R1-Short isoform that modulates IL-18 signaling across species.

TEPEAK identifies and characterizes polymorphic transposable elements in non-model species populations using genome and SRA data, revealing genetic disruptions and TE presence in related species.

The paper assembles and annotates the first whole genome of the ball python (Python regius), providing a high-quality resource for studying snake-specific traits and physiological adaptations.

This study identifies SP140's role in regulating IFN-β mRNA stability through RESIST, revealing a dual antiviral and interferon regulatory function.

The paper presents high-quality de novo genome assemblies for two dwarf honey bee species using hybrid sequencing, showing improved contiguity and completeness compared to previous studies.

The paper identifies transposon exonization as a mechanism regulating interferon signaling by generating functional variants of immune genes, including a decoy receptor that inhibits interferon signaling.

The paper identifies ERV-derived enhancers as drivers of transcriptional rewiring in colorectal cancer through oncogenic AP1/MAPK signaling.

The paper identifies B2 SINE elements as IFN-inducible enhancers in mouse cells, showing their role in regulating immune genes like Dicer1 and Serpina3f/g.

The paper introduces 4Tran, a method to study transposon interactions in the genome, revealing their role in chromatin organization and gene regulation.