Author

Irène Marchetti

Sangamo BioSciences (United States)ORCID 0009-0002-6605-9614Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Assay:CRISPR screen· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Andreas Reik· 2 shared Angélique E. Martelli· 2 shared Caroline Jeanneau· 2 shared Coralie F DupontiD· 2 shared David FenardiD· 2 shared Davide MonteferrarioiD· 2 shared Gaëlle Saviane· 2 shared Lynn N. Truong· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Andreas Reik

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2 papers

Recent·Most cited

Cancer BiologyMolecular Therapy OncologyPeer-reviewedMay 7, 2025

Enhanced anti-tumor activity by Zinc Finger Repressor-driven epigenetic silencing of immune checkpoints and TGFBR2 in CAR-T cells and TILs

Marion David, Phillip Schiele, Davide Monteferrario…·David Fenard

This paper enhances CAR-T cell and TIL anti-tumor activity by epigenetically silencing immune checkpoints and TGFBR2 using Zinc Finger Repressors.

5 citations

𝕏 PostBluesky

BioengineeringMolecular Therapy — Methods & Clinical DevelopmentPeer-reviewedApr 23, 2024

Epigenetic control of multiple genes with a single lentiviral vector encoding transcriptional repressors fused to compact zinc finger arrays

Davide Monteferrario, Marion David, Satish Kumar Tadi…·David Fenard

This paper develops a lentiviral system to simultaneously repress multiple genes using zinc finger repressors, showing efficient and long-term gene silencing without DNA editing.

2 citations

humanCRISPR screen

𝕏 PostBluesky