Satish Kumar Tadi

This paper enhances CAR-T cell and TIL anti-tumor activity by epigenetically silencing immune checkpoints and TGFBR2 using Zinc Finger Repressors.

This paper develops a lentiviral system to simultaneously repress multiple genes using zinc finger repressors, showing efficient and long-term gene silencing without DNA editing.

The paper identifies Ku-binding motifs in RAG2, XLF, PAXX, and MRI that mediate their interactions with Ku and support functional redundancy during V(D)J recombination.