Author

Laura C. McCoullough

The Royal Melbourne HospitalORCID 0009-0002-6770-3889Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Joseph A. TrapaniiD· 1 shared Mai Anh Thu Le· 1 shared Margaret LittlejohniD· 1 shared Mohamed FarehiD· 1 shared Peter A. RevilliD· 1 shared Yi Wen Liaw· 1 shared Zak T. JanetzkiiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperMicrobiology

Joseph A. TrapaniORCID

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1 paper

Recent·Most cited

Addressing viral genomic variability towards developing a Cas13b-based therapy

Mai Anh Thu Le, Laura C. McCoullough, Zak T. Janetzki, Yi Wen Liaw, Mohamed Fareh, Joseph A. Trapani, Peter A. Revill, Margaret Littlejohn

This study evaluates how viral genomic variability affects CRISPR-Cas13b efficacy against hepatitis B virus, showing that mismatched guide RNAs reduce antiviral activity and that sequence specificity is not the sole determinant of efficacy.

bioRxiv · Jul 17, 2026 · PreprintMicrobiology