Author

Mai Anh Thu Le

The Royal Melbourne Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Joseph A. TrapaniiD· 1 shared Laura C. McCoulloughiD· 1 shared Margaret LittlejohniD· 1 shared Mohamed FarehiD· 1 shared Peter A. RevilliD· 1 shared Yi Wen Liaw· 1 shared Zak T. JanetzkiiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperMicrobiology

Joseph A. TrapaniORCID

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1 paper

Recent·Most cited

MicrobiologybioRxivPreprintJul 17, 2026

Addressing viral genomic variability towards developing a Cas13b-based therapy

Mai Anh Thu Le, Laura C. McCoullough, Zak T. Janetzki…·Margaret Littlejohn

This study evaluates how viral genomic variability affects CRISPR-Cas13b efficacy against hepatitis B virus, showing that mismatched guide RNAs reduce antiviral activity and that sequence specificity is not the sole determinant of efficacy.

DOI 10.64898/2026.07.16.739033

humanCRISPR screen

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