Author

Mona Miraftab

National Cancer InstituteORCID 0009-0002-6903-2986Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:whole-genome sequencing· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:variant calling· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Angela Cecilia PesatoriiD· 4 shared Azhar KhandekariD· 4 shared Caleb HartmaniD· 4 shared Charles LeduciD· 4 shared Dario ConsonniiD· 4 shared John P. McElderryiD· 4 shared Kristine M. JonesiD· 4 shared Lixing YangiD· 4 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenomics

Angela Cecilia PesatoriORCID

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4 papers

Recent·Most cited

Examining the Role of Extrachromosomal DNA in Lung Cancer

Azhar Khandekar, Phuc H. Hoang, Jens Luebeck, Marcos Díaz‐Gay, Wei Zhao, John P. McElderry, Caleb Hartman, Mona Miraftab, Olivia W. Lee, Kara Marie Barnao, Kristine M. Jones, Amy Hutchinson, Belynda D. Hicks, Erik N. Bergstrom, Yang Yang, , Maria Teresa Landi

This study examines ecDNA in lung cancer, finding it in 18.9% of patients and associating it with worse survival and genomic instability.

JNCI Journal of the National Cancer Institute · Aug 1, 2026Peer-reviewedBioinformatics

Revealing the Drivers Underlying Distinct Evolutionary Trajectories in Lung Adenocarcinoma

Christopher Wirth, Tongwu Zhang, Marcos Díaz‐Gay, Christopher D. Steele, Phuc H. Hoang, Yang Yang, Azhar Khandekar, Wei Zhao, Jian Sang, Charles Leduc, Marina K. Baine, W. Travis, Lynette Marie Sholl, Philippe Joubert, Robert Homer, , Maria Teresa Landi

This study identifies three distinct evolutionary trajectories in lung adenocarcinomas using whole-genome sequencing, revealing that some never-smoking tumors follow smoking-like paths driven by KRAS mutations.

bioRxiv · Dec 23, 2025 · PreprintCancer Biology

A prognostic signature for lung adenocarcinoma in people who have never smoked

Wei Zhao, Tongwu Zhang, Xing Hua, Phuc H. Hoang, Mona Miraftab, Monjoy Saha, John P. McElderry, Jian Sang, Olivia W. Lee, Caleb Hartman, Azhar Khandekar, Sunandini Sharma, Frank J. Colón-Matos, Samuel Anyaso-Samuel, Difei Wang, , Maria Teresa Landi

The paper identifies three subtypes of NS-LUAD using RNA-seq data and develops a 60-gene signature that predicts survival across subgroups.

bioRxiv · Aug 13, 2025 · PreprintGenomics

Deciphering lung adenocarcinoma evolution and the role of LINE-1 retrotransposition

Tongwu Zhang, Wei Zhao, Christopher Wirth, Marcos Díaz‐Gay, Jinhu Yin, Monia Cecati, Francesca Marchegiani, Phuc H. Hoang, Charles Leduc, Marina K. Baine, William David Travis, Lynette Marie Sholl, Philippe Joubert, Jian Sang, John P. McElderry, , Maria Teresa Landi

This study analyzes 1024 lung adenocarcinomas to identify evolutionary patterns and mutational mechanisms, revealing distinct trajectories linked to smoking, ancestry, and retrotransposition.

bioRxiv · Mar 14, 2025 · PreprintGenomics