JNCI Journal of the National Cancer InstituteBioinformaticsPeer-reviewed journal article
Examining the Role of Extrachromosomal DNA in Lung Cancer
Azhar KhandekariD, Phuc H. HoangiD, Jens LuebeckiD, Marcos Díaz‐GayiD, Wei ZhaoiD, John P. McElderryiD, Caleb HartmaniD, Mona MiraftabiD, Olivia W. LeeiD, Kara Marie BarnaoiD, Kristine M. JonesiD, Amy HutchinsoniD, Belynda D. HicksiD, Erik N. BergstromiD, Yang Yang, Martin A. NowakiD, Nathaniel RothmaniD, Angela Cecilia PesatoriiD, Dario ConsonniiD, Robert HomeriD, Marina K. BaineiD, Lynette Marie SholliD, Philippe JoubertiD, Charles LeduciD, William David TravisiD, , Maria Teresa LandiiD
Abstract
The role of extrachromosomal DNA (ecDNA) in lung cancer, particularly in subjects who never smoked (LCINS), remains unclear. Examination of over 1200 whole-genome-sequenced lung cancers identified ecDNA in 18.9% of patients. Recurrent amplification of MDM2 and other oncogenes via ecDNA possibly drives a LCINS subset. Tumors harboring ecDNA showed worse overall survival than tumors harboring other focal amplifications. A strong association with whole-genome doubling suggests most ecDNA reflects genomic instability in treatment-naive lung cancer.
- organism: human
- assay: whole-genome sequencing
- research focus: variant calling
- approach: statistical model
- Citations
- 6
- FWCI
- 12.82
- Field percentile
- top 1%
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