Robert Homer

This study examines ecDNA in lung cancer, finding it in 18.9% of patients and associating it with worse survival and genomic instability.

This study identifies early alveolar niche disruption and aberrant epithelial reprogramming in IPF using multi-modal analyses of patient cohorts.

The paper develops a Fiji plugin to measure alveolar chord length and septal thickness in BPD research, validated across animal models and human lungs.

This paper develops a deep learning model to predict molecular alterations in never-smoker lung adenocarcinomas from histological images, achieving high accuracy for most features.

This study identifies three distinct evolutionary trajectories in lung adenocarcinomas using whole-genome sequencing, revealing that some never-smoking tumors follow smoking-like paths driven by KRAS mutations.

This study creates a spatial transcriptomics atlas of human tuberculosis and non-tuberculous mycobacterial granulomas, identifying distinct niches and immune signatures.

Intranasal hemagglutinin boosters after mRNA-LNP vaccination induce mucosal immunity and cross-protection against influenza A virus in mice.

The paper identifies three subtypes of NS-LUAD using RNA-seq data and develops a 60-gene signature that predicts survival across subgroups.

Single-nucleus multiomic and ex vivo lung slice profiling of human idiopathic pulmonary fibrosis identifies Alveolar Intermediate cells bridging alveolar and Aberrant Basaloid states and reveals AP-1 chromatin injury memory.

This study analyzes 1024 lung adenocarcinomas to identify evolutionary patterns and mutational mechanisms, revealing distinct trajectories linked to smoking, ancestry, and retrotransposition.

This study shows that SLPI deficiency in mice infected with B. burgdorferi leads to increased joint inflammation and immune cell infiltration.

This study develops an engineered whole-lung tissue model to study tissue organization and alveolar barrier function, showing improved barrier function with alveolar macrophages.

The paper identifies a nerve-fibroblast axis in lung fibrosis by integrating multiple experimental and computational approaches across species.

The paper identifies two lung cancer subtypes defined by APOBEC mutagenesis levels and shows their association with different genetic mutations, aging, and immune responses.

SDePER improves cell type deconvolution in spatial transcriptomic data by addressing platform effects, sparsity, and spatial correlation, achieving more accurate results than existing methods.

This study identifies TKS5-mediated podosome formation in IPF fibroblasts as a driver of ECM invasion and pulmonary fibrosis, with potential therapeutic targeting via src kinase inhibition.

This study shows that time to first cigarette strongly influences lung tumor mutational burden, signatures, and survival in smokers.

This study uses single-cell RNA-seq to identify aberrant cell populations in IPF lungs, revealing novel basaloid cells and vascular endothelial changes.