An atlas of microtubule lattice parameters regulated through ligand binding to the microtubule stabilizing sites.
Daniel Lucena‐Agell, Óscar Fernández, Rebeca París-Ogáyar, Juan Estévez‐Gallego, Denisa Ondruskova, Beatriz Álvarez-Bernad, Francesca Bonato, Jaime Larraga, D. Ortiz de Elguea, Gregorio Javier Cano, Marvin Scheers, Hiroshi Imai, Toshiki Yagi, Hiroyuki Iwamoto, Juan Carlos Martínez-Guil, , José Fernando Díaz
This paper investigates how microtubule-stabilizing ligands alter lattice conformation and function, showing they stabilize distinct longitudinal states that affect nucleotide hydrolysis and motor protein interactions.
Proceedings of the National Academy of Sciences · Jun 16, 2026Peer-reviewedBiophysics