Hiroyuki Iwamoto

Androgen receptor determines skeletal muscle sexual dimorphism

This study identifies AR-dependent Mybph repression as a mechanism contributing to skeletal muscle sexual dimorphism using ChIL-seq and an AirID-AR knock-in mouse.

An atlas of microtubule lattice parameters regulated through ligand binding to the microtubule stabilizing sites.

This paper investigates how microtubule-stabilizing ligands alter lattice conformation and function, showing they stabilize distinct longitudinal states that affect nucleotide hydrolysis and motor protein interactions.

Dysregulated Skeletal Muscle Myosin Super-relaxation and Energetics in Type II Diabetes

This study investigates altered myosin super-relaxation and energy metabolism in type II diabetes using muscle biopsies and proteomic analyses, finding increased super-relaxation and reduced ATP demand.

Restoration of 3-D structure of insect flight muscle from a rotationally averaged 2-D X-ray diffraction pattern

The paper demonstrates restoring 3-D structure of insect flight muscle from a 2-D X-ray diffraction pattern using phase-retrieval algorithm.