Improved in situ Characterization of Proteome-wide Protein Complex Dynamics with Thermal Proximity Co-Aggregation
Siyuan Sun, Zhenxiang Zheng, Jun Wang, Fengming Li, An He, Ruijun Tian, Chris Soon Heng Tan
The paper introduces Slim-TPCA, an optimized method for proteome-wide characterization of protein complex dynamics, showing improved throughput and accuracy in identifying complex dissociation and association under glucose deprivation.
bioRxiv · Feb 13, 2023 · PreprintBioinformatics