Jun Wang

This study presents the structures of the Vγ9Vδ2 TCR in inactive and agonist-crosslinked states, revealing a dimerization-driven activation mechanism.

The paper identifies progranulin as a mediator of immune suppressive niches in brain metastasis using cross-species spatial transcriptomics and functional analyses.

This study shows that deleting SHP1 and SHP2 in T cells increases CD4+ T cell activation-induced cell death and reduces antitumor responses, with SHP2 loss enhancing anti-PD-1 therapy.

scBubbletree provides a scalable visualization method for scRNA-seq data by clustering cells into bubbles on dendrograms, enabling quantitative assessment and biological interpretation.

The paper introduces Slim-TPCA, an optimized method for proteome-wide characterization of protein complex dynamics, showing improved throughput and accuracy in identifying complex dissociation and association under glucose deprivation.

This study compares transcriptomes from SARS-CoV-2, SARS-CoV, and MERS-CoV infections to investigate alternative entry routes and innate immune responses.