Author

Sem A.G. Engels

Princess Máxima CenterORCID 0009-0002-8765-3524Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:imaging· 1 Assay:long-read sequencing· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander van OudenaardeniD· 1 shared Ana Inés LalanneiD· 1 shared Ana P. LopesiD· 1 shared Burkhard LehneriD· 1 shared Christina MichailiD· 1 shared Clémence HenoniD· 1 shared Eivind ValeniD· 1 shared Emma G. A. Westerink· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alexander van OudenaardenORCID

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1 paper

Recent·Most cited

Oncogenic fusions induce an extensive cancer-restricted cryptic proteome in Ewing sarcoma

Luuk A. Broeils, Jill Pilet, Maria K. Koshkina, Jing Li, Sandrine Grossetête, Emma G. A. Westerink, Orson Jay, Lotta Smit, Ting Luo, Erkan Narmanli, Ana P. Lopes, Florian H. Geyer, Sem A.G. Engels, Clémence Henon, Karim Aljakouch, , Sebastiaan van Heesch

The paper shows EWSR1::FLI1 fusion drives the production of cancer-specific neoproteins in Ewing sarcoma, revealing a reversible dark proteome with therapeutic potential.

bioRxiv · Sep 17, 2026 · PreprintCancer Biology