Author

Clémence Henon

German Cancer Research CenterORCID 0000-0001-7893-3116Unclaimed ORCID profile · follow to get notified of new preprints

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:deep learning· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Thomas G. P. GrünewaldiD· 4 shared Florencia Cidre‐AranaziD· 3 shared Florian H. GeyeriD· 3 shared Jing LiiD· 3 shared Olivier DelattreiD· 3 shared Alina Ritter· 2 shared Ana BanitoiD· 2 shared Anna C. EhlersiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersCancer Biology

Thomas G. P. GrünewaldORCID

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4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 17, 2026

Functional spatial transcriptomics uncover LMO7 as a fusion-regulated and clinically relevant driver of metastasis in Ewing sarcoma

Veronika Buršić, Heng Luo, Clémence Henon…·Florencia Cidre‐Aranaz

The paper identifies LMO7 as a fusion-regulated driver of metastasis in Ewing sarcoma using spatial transcriptomics and integrates clinical data to show its association with poor outcomes.

DOI 10.64898/2026.08.27.747513

humanspatial transcriptomics

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Cancer BiologybioRxivPreprintSep 17, 2026

Oncogenic fusions induce an extensive cancer-restricted cryptic proteome in Ewing sarcoma

Luuk A. Broeils, Jill Pilet, Maria K. Koshkina…·Sebastiaan van Heesch

The paper shows EWSR1::FLI1 fusion drives the production of cancer-specific neoproteins in Ewing sarcoma, revealing a reversible dark proteome with therapeutic potential.

DOI 10.64898/2026.09.16.751792

humanscRNA-seq

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Cancer BiologybioRxivPreprintMay 16, 2025

Dynamic oncogene activity metabolically reprograms the tryptophan-kynurenine-AHR axis driving immune evasion and tumor progression in Ewing sarcoma

Martha Julia Carreño-Gonzalez, Kimberley M. Hanssen, Ahmed Sadik…·Thomas G. P. Grünewald

This study shows that reduced EWSR1::ETS activity in Ewing sarcoma promotes immune evasion via the tryptophan-kynurenine-AHR axis, leading to worse clinical outcomes and tumor progression.

2 citations

humanmetabolomics

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Cancer Biology癌症：英文版Peer-reviewedMar 15, 2025

Super-enhancer-driven CACNA2D2 is an EWSR1::WT1 signature gene encoding a diagnostic marker for desmoplastic small round cell tumor (DSRCT)

Florian H. Geyer, Alina Ritter, Seneca S. Kinn-Gurzo…·Florencia Cidre‐Aranaz

The paper identifies CACNA2D2 as a super-enhancer-driven target of EWSR1::WT1 and demonstrates its utility as a diagnostic biomarker for DSRCT.

12 citationstop 4%

humanscRNA-seq

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