Cancer BiologyJCI InsightPeer-reviewed
Mitochondrial defects and metabolic vulnerabilities in Lynch syndrome-associated MSH2-deficient endometrial cancer
Mikayla Borthwick Bowen, Brenda Melendez, Qian Zhang…·Melinda S. Yates
This study identifies mitochondrial dysfunction and metabolic reprogramming in MSH2-deficient endometrial cancer, revealing a novel pathway and potential therapeutic targets.