Mitochondrial defects and metabolic vulnerabilities in Lynch syndrome-associated MSH2-deficient endometrial cancer
Mikayla Borthwick Bowen, Brenda Melendez, Qian Zhang, Diana Moreno, Leah Peralta, WaiKin Chan, Collene R. Jeter, Lin Tan, Malgorzata Anna Zal, Philip L. Lorenzi, Kenneth Dunner, Richard Kenneth Yang, Russell R. Broaddus, Joseph Celestino, Nisha Gokul, , Melinda S. Yates
This study identifies mitochondrial dysfunction and metabolic reprogramming in MSH2-deficient endometrial cancer, revealing a novel pathway and potential therapeutic targets.
JCI Insight · Feb 18, 2025Peer-reviewedCancer Biology