Author

Qian Zhang

Cold Spring Harbor LaboratoryORCID 0000-0003-4928-3366Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Qian Zhang23 papers · Virginia Tech

Biology Disciplines

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Cancer Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Adrian R. KraineriD· 1 shared Brenda MelendeziD· 1 shared Chen CheniD· 1 shared Chen‐Song ZhangiD· 1 shared Collene R. JeteriD· 1 shared Deena M ScovilleiD· 1 shared Diana Moreno· 1 shared Elizabeth M. WhitleyiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperMolecular Biology

Adrian R. KrainerORCID

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3 papers

Recent·Most cited

Cancer BiologyJCI InsightPeer-reviewedFeb 18, 2025

Mitochondrial defects and metabolic vulnerabilities in Lynch syndrome-associated MSH2-deficient endometrial cancer

Mikayla Borthwick Bowen, Brenda Melendez, Qian Zhang…·Melinda S. Yates

This study identifies mitochondrial dysfunction and metabolic reprogramming in MSH2-deficient endometrial cancer, revealing a novel pathway and potential therapeutic targets.

11 citationstop 2%

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Cancer BiologybioRxivPreprintFeb 15, 2025

AMPK- and cGAS-Mediated Dual Sensing of Glucose and dsDNA Synergizes to Enhance Antitumor Immunity

Ruyuan Zhou, Jingyan Pei, Shasha Chen…·Pinglong Xu

This study identifies a mechanism where AMPK and cGAS-STING signaling synergize through glucose and dsDNA sensing to enhance antitumor immunity in melanoma and colorectal cancer.

DOI 10.1101/2025.02.15.638470

mouseexperimental assay

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Molecular BiologyNature CommunicationsPeer-reviewedMay 27, 2022

Gene-Specific Nonsense-Mediated mRNA Decay Targeting for Cystic Fibrosis Therapy

Young Jin Kim, Tomoki T. Nomakuchi, Foteini Papaleonidopoulou…·Adrian R. Krainer

This study develops a cocktail of ASOs to specifically increase CFTR W1282X mRNA and protein levels by inhibiting NMD, improving chloride current in human bronchial epithelial cells.

41 citationstop 3%

humanexperimental assay

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