Enhanced Sequence-Activity Mapping and Evolution of Artificial Metalloenzymes by Active Learning
Tobias Vornholt, Mojmír Mutný, Gregor W. Schmidt, Christian Schellhaas, Ryo Tachibana, Sven Panke, Thomas R. Ward, Andreas Krause, Markus Jeschek
This paper improves enzyme engineering by combining active learning and experimental screening to efficiently discover high-performing artificial metalloenzymes.
ACS Central Science · May 22, 2024Peer-reviewedSynthetic Biology