Thomas R. Ward

This paper engineers a biotin-independent Saccharomyces cerevisiae strain by bypassing acetyl-CoA carboxylase, enabling growth without biotin and improved malonate utilization.

This paper improves enzyme engineering by combining active learning and experimental screening to efficiently discover high-performing artificial metalloenzymes.

This paper introduces a systematic platform for engineering artificial metalloenzymes to enhance their catalytic activity for new-to-nature reactions.