Author

Ghassan S. Makhoul

Vanderbilt UniversityORCID 0009-0002-9281-541XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:electronic health records· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Research Focus:benchmarking· 1 Research Focus:clustering· 1 Research Focus:dimensionality reduction· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Christos ConstantinidisiD· 4 shared Dario J. EnglotiD· 4 shared Derek J. DossiD· 4 shared Graham Walter JohnsoniD· 4 shared Sarah K. B. BickiD· 4 shared Shawniqua Williams RobersoniD· 4 shared Angela N. Crudele· 3 shared Benoît M. DawantiD· 3 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Christos ConstantinidisORCID

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Author profile →

4 papers

Recent·Most cited

Generalized brain-state modeling with KenazLBM

Graham Walter Johnson, Ghassan S. Makhoul, Derek J. Doss, Bruno Hidalgo Monroy Lerma, Leon Y. Cai, Emily Liao, Danika Lea Paulo, Anas J. Reda, C Price Withers, Addison C. Cavender, Helen Qian, Derrick Obiri‐Yeboah, Kobina G. Mensah-Brown, Panagiotis Kerezoudis, Matthew R. Baker, , Dario J. Englot

KenazLBM is a model that characterizes and predicts brain states from raw iEEG data, generalizing across subjects with heterogeneous recording channels.

bioRxiv · Aug 10, 2025 · PreprintNeuroscience

Collapse of Interictal Suppressive Networks Permits Seizure Spread

Ghassan S. Makhoul, Derek J. Doss, Graham Walter Johnson, C Price Withers, Addison C. Cavender, Bruno Hidalgo Monroy Lerma, Anas J. Reda, Camden E. Bibro, Emily Liao, Hakmook Kang, Benoît M. Dawant, Shilpa B. Reddy, Angela N. Crudele, Christos Constantinidis, Shawniqua Williams Roberson, , Dario J. Englot

This paper analyzes peri-ictal network dynamics in drug-resistant epilepsy patients to show that NIZs increase inhibitory signaling to SOZs during seizures, but this suppression is insufficient to prevent seizure onset.

Brain · Jun 5, 2025Peer-reviewedNeuroscience

Reward Circuit Local Field Potential Modulations Precede Risk Taking

Natasha Hughes, Helen Qian, Derek J. Doss, Ghassan S. Makhoul, Michael Zargari, Zixiang Zhao, Balbir Singh, Zhengyang Wang, Jenna N. Fulton, Graham Walter Johnson, Rui Li, Benoît M. Dawant, Dario J. Englot, Christos Constantinidis, Shawniqua Williams Roberson, Sarah K. B. Bick

This study identifies reward circuitry activity predictive of risk-taking in humans using local field potential recordings during a gambling task.

Brain · Mar 17, 2025Peer-reviewedNeuroscience

Brain-state modeling using electroencephalography: Application to adaptive closed-loop neuromodulation for epilepsy

Graham Walter Johnson, Derek J. Doss, Ghassan S. Makhoul, Leon Y. Cai, Camden E. Bibro, Danika Lea Paulo, Shilpa B. Reddy, Robert Partlow Naftel, Kevin F. Haas, Mark T. Wallace, Benoît M. Dawant, Angela N. Crudele, Victoria L. Morgan, Christos Constantinidis, Shawniqua Williams Roberson, , Dario J. Englot

This paper introduces BrainState, a self-supervised method to model complex brain states from EEG data, applied to epilepsy patients to capture pre-seizure states and neuromodulation effects.

bioRxiv · Jun 1, 2024 · PreprintNeuroscience