Cryo-EM Reveals VP1/VP2 N-Terminal Conformations in Adeno-Associated Virus 2 Capsids.
Innocent O. Osuya, S. Shirin Kamalaldinezabadi, Ananya Sengupta, Gwimoon Seo, Michael Stewart Chapman, Scott M. Stagg
The paper uses cryo-EM to reveal distinct N-terminal conformations of VP1/VP2 in AAV2 capsids with different VP stoichiometries, linking them to structural heterogeneity.
bioRxiv · Oct 17, 2026 · PreprintBiophysics