S. Shirin Kamalaldinezabadi

Stimulating microglial neuroinflammation with amyloid-beta oligomers compatible with solid-state NMR structural characterization

This paper develops a detergent-free method to produce Aβ42 oligomers compatible with solid-state NMR and shows they induce stronger microglial inflammation than monomers.

Cryo-EM Reveals VP1/VP2 N-Terminal Conformations in Adeno-Associated Virus 2 Capsids.

The paper uses cryo-EM to reveal distinct N-terminal conformations of VP1/VP2 in AAV2 capsids with different VP stoichiometries, linking them to structural heterogeneity.

Structural Co-optation and Loss-of-function Underlie the Evolution of Regulatory Novelty in the Glucokinase Regulatory Protein

This study identifies a single mutation that enables GKRP to gain small-molecule allostery through structural co-optation, without requiring new genetic material.

Evolution of Protein Regulation in the Vertebrate Glucose Sensor

This paper reconstructs extinct glucokinase (GCK) and glucokinase regulatory protein (GKRP) to study the evolutionary origins of protein regulation in vertebrate glucose homeostasis.

Aggregation Dynamics of a 150 kDa Aβ42 Oligomer: Insights from Cryo Electron Microscopy and Multimodal Analysis

This study examines the aggregation dynamics of a 150 kDa Aβ42 oligomer using cryo-EM and other techniques, revealing unique string-like assemblies distinct from classical fibrils.