Scott M. Stagg

This paper develops a detergent-free method to produce Aβ42 oligomers compatible with solid-state NMR and shows they induce stronger microglial inflammation than monomers.

The paper uses cryo-EM to reveal distinct N-terminal conformations of VP1/VP2 in AAV2 capsids with different VP stoichiometries, linking them to structural heterogeneity.

CryoSift automates 2D class selection in cryo-EM by using a CNN to assess particle quality, enabling high-throughput processing for high-resolution reconstructions.

Magellon provides a flexible and scalable cryo-EM platform with microservices architecture for data management, processing, and visualization.

This study determines the structure of Drp1 on lipid membranes, revealing a locally ordered lattice and conformational changes that suggest a ratchet mechanism for mitochondrial constriction.

This study examines the aggregation dynamics of a 150 kDa Aβ42 oligomer using cryo-EM and other techniques, revealing unique string-like assemblies distinct from classical fibrils.

This study identifies structural and functional roles of TFG ring complexes in neuronal cargo trafficking, showing how mutations disrupt their stability and contribute to neurodegenerative disease.

The paper introduces SPOT-RASTR, a cryo-EM technique using lipid nanotubes to overcome air-water interface and preferred orientation issues, enabling automated data collection and near-atomic resolution.

The paper presents the structure of a Type III-A CRISPR-Cas effector complex from S. epidermidis, revealing interactions with target RNA and crRNA and highlighting differences among related systems.