NAD+ activates renal metabolism and protects from chronic kidney disease in a model of Alport syndrome
Bryce A. Jones, Debora L. Gisch, Komuraiah Myakala, Amber Sadiq, Ying‐Hua Cheng, Elizaveta Taranenko, Julia Panov, Kyle E. Korolowicz, Ricardo Melo Ferreira, Xiaoping Yang, Briana A. Santo, Katherine C. Allen, Teruhiko Yoshida, Xiaoxin X. Wang, Avi Z. Rosenberg, , Moshe Levi
This study shows that NAD+ supplementation protects against CKD in Alport syndrome by restoring FAO in proximal tubule cells and reveals sex differences in transcriptional responses.
JCI Insight · Mar 9, 2025Peer-reviewedMolecular Biology