Debora L. Gisch

This study identifies a MEF2C transcription factor network that regulates endothelial cell proliferation in diabetic kidney disease and shows that SGLT2i treatment can reverse its dysregulation.

The paper builds a cross-species single-cell multi-omics kidney atlas to identify epithelial cells as a driver of epigenetic aging in diseased kidneys.

The paper presents a multi-modal atlas of human kidney disease, identifying cellular and spatial mechanisms of injury resolution or failure and linking them to clinical outcomes.

This study shows cannabidiol increases T effector memory cells and has mixed inflammatory effects in humans.

This study shows that NAD+ supplementation protects against CKD in Alport syndrome by restoring FAO in proximal tubule cells and reveals sex differences in transcriptional responses.

The paper defines the chromatin landscape of healthy and injured kidney cells using multi-omics data, identifying regulatory elements and transcription factor networks involved in injury response.