Briana A. Santo

This study identifies survivin as a mechanosensitive regulator linking ECM stiffness to GBM growth and matrisome remodeling, suggesting it as a therapeutic target.

The paper creates a poly(A) isoform-aware single-cell and spatial atlas of the human bladder, identifying fibroblast niches and their spatial relationships.

This paper identifies radiomic features from CT scans that predict neutrophil extracellular trap (NET) enrichment in ischemic stroke clots, which correlates with mechanical thrombectomy success.

This study shows that NAD+ supplementation protects against CKD in Alport syndrome by restoring FAO in proximal tubule cells and reveals sex differences in transcriptional responses.

The paper investigates how alternative polyadenylation (APA) regulates urothelial differentiation using single-cell RNA-seq and spatial imaging, showing APA's role in shaping cell state-specific polyadenylation sites and transcriptome diversity.

ComPRePS improves renal pathology analysis by automating WSI processing and AI-assisted interpretation, enhancing precision and interobserver agreement in key lesion assessments.