Author

Jacob Popolow

University of PennsylvaniaORCID 0009-0003-0141-0263Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Erika L.F. HolzbauriD· 2 shared Carris Temera BorlandiD· 1 shared Juliet GoldsmithiD· 1 shared Sierra D. PalumbosiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 4 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Erika L.F. HolzbaurORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

KIF1A-mediated trafficking is required for neuronal autophagy in human neurons

Carris Temera Borland, Jacob Popolow, Erika L.F. Holzbaur

This study shows that KIF1A mutations impair autophagy in human neurons by disrupting ATG9 trafficking and lysosomal function, contributing to KAND pathogenesis.

bioRxiv · Jul 24, 2026 · PreprintNeuroscience

Autophagic stress activates distinct compensatory secretory pathways in neurons

Sierra D. Palumbos, Jacob Popolow, Juliet Goldsmith, Erika L.F. Holzbaur

The paper shows that neurons with Parkinson's disease-associated LRRK2 mutations increase secretion of autophagosomes and exosomes to manage cellular waste and communication, potentially delaying disease onset but contributing to neuroinflammation.

Proceedings of the National Academy of Sciences · Jul 7, 2025Peer-reviewedNeuroscience