Author

Sierra D. Palumbos

Vanderbilt UniversityORCID 0000-0002-3595-984XUnclaimed ORCID profile · follow to get notified of new preprints

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Organism:C. elegans· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:imaging· 1

Frequent Co-Authors

David M. MilleriD· 4 shared Andrea Cuentas-CondoriiD· 2 shared Rebecca D. McWhirter· 2 shared Alex HajnaliD· 1 shared ALEXANDER R. GOTTSCHALKiD· 1 shared Alexandra Oranth· 1 shared Amanda Mitchell· 1 shared Andreas LehaiD· 1 shared

Activity by Year

2019-2025 · peak 2/yr

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10 top collaborators · 20 mutual co-author links

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4 shared papersNeuroscience

David M. MillerORCID

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5 papers

Recent·Most cited

Autophagic stress activates distinct compensatory secretory pathways in neurons

Sierra D. Palumbos, Jacob Popolow, Juliet Goldsmith, Erika L.F. Holzbaur

The paper shows that neurons with Parkinson's disease-associated LRRK2 mutations increase secretion of autophagosomes and exosomes to manage cellular waste and communication, potentially delaying disease onset but contributing to neuroinflammation.

Proceedings of the National Academy of Sciences · Jul 7, 2025Peer-reviewedNeuroscience

cAMP controls a trafficking mechanism that directs the neuron specificity and subcellular placement of electrical synapses

Sierra D. Palumbos, Rachel L. Skelton, Rebecca D. McWhirter, Amanda Mitchell, Isaiah Swann, Sydney Heifner, Stephen E. Von Stetina, David M. Miller

The paper shows cAMP signaling directs gap junction trafficking to assemble and position electrical synapses in C. elegans motor neurons.

Developmental Cell · Nov 5, 2021Peer-reviewedNeuroscience

Transcriptional control of parallel-acting pathways that remove discrete presynaptic proteins in remodeling neurons

Tyne W. Miller‐Fleming, Andrea Cuentas-Condori, Laura Manning, Sierra D. Palumbos, Janet E. Richmond, David M. Miller

The paper identifies a transcriptional pathway regulated by IRX-1 that drives the removal of presynaptic proteins during neuronal remodeling in C. elegans.

Journal of Neuroscience · May 27, 2021Peer-reviewedNeuroscience

Epidermal Growth Factor signaling acts directly and through a sedation neuron to depolarizes a sleep-active neuron following cellular stress

Jan Konietzka, Maximilian Fritz, Silvan Spiri, Rebecca D. McWhirter, Andreas Leha, Sierra D. Palumbos, Wagner Steuer Costa, Alexandra Oranth, ALEXANDER R. GOTTSCHALK, David M. Miller, Alex Hajnal, Henrik Bringmann

The paper identifies EGFR signaling in the RIS neuron and its indirect activation via the ALA neuron as mechanisms for sleep induction following cellular stress in C. elegans.

Current Biology · Dec 12, 2019Peer-reviewedNeuroscience

Dendritic spines on GABAergic neurons respond to cholinergic signaling in the Caenorhabditis elegans motor circuit.

Andrea Cuentas-Condori, Ben Mulcahy, Siwei He, Sierra D. Palumbos, Mei Zhen, David M. Miller

The paper identifies functional dendritic spines in C. elegans GABAergic motor neurons and describes their structural and functional characteristics.

bioRxiv · Apr 15, 2019 · PreprintNeuroscience