Shimin Wang

This paper develops a hierarchical sequence-based framework to infer distributed protein organization, identifies novel ciliary proteins, and enables synthetic protein design.

TaoChongBao is a database of C. elegans missense variants linked to human pathogenic sites, offering expanded mutation coverage and tools for variant interpretation and comparative genomics.

The paper introduces a cost-effective WGS method for model organisms to validate missense variant predictions.

The paper develops a machine learning-based EMS mutagenesis probability map to identify causal mutations in C. elegans without generating recombinant inbred lines.