Zi Wang

TaoChongBao is a database of C. elegans missense variants linked to human pathogenic sites, offering expanded mutation coverage and tools for variant interpretation and comparative genomics.

This study identifies GPCR-Gαq signaling as a mechanism of adaptive resistance to MEK inhibition in BRAF-mutant melanoma, showing that targeting this pathway can restore drug sensitivity.

The paper introduces a cost-effective WGS method for model organisms to validate missense variant predictions.

The paper develops a machine learning-based EMS mutagenesis probability map to identify causal mutations in C. elegans without generating recombinant inbred lines.