Yongping Chai

Spatially Confined Phase Separation Promotes Local Tubulin Availability to Stabilize Ciliary Microtubule Growth

This study identifies RAT-1 as a regulator of ciliary microtubule dynamics through spatially confined phase separation that stabilizes tubulin availability for MT growth.

Integrating structural and biological evidence to rerank ESMFold2 protein-protein interactions

The paper develops a framework to rerank protein-protein interactions using structural and biological evidence, improving prediction accuracy over structural-only methods.

Hierarchical latent representations reveal protein organization for functional discovery and design

This paper develops a hierarchical sequence-based framework to infer distributed protein organization, identifies novel ciliary proteins, and enables synthetic protein design.

TaoChongBao: A Large-Scale Caenorhabditis elegans Mutagenesis and Missense Variant Database Bridging Worm and Human Genomes

TaoChongBao is a database of C. elegans missense variants linked to human pathogenic sites, offering expanded mutation coverage and tools for variant interpretation and comparative genomics.

A comprehensive functional landscape of α-tubulin TUBA1A variants illuminates microtubule biology and refines clinical classification

The paper systematically assesses the functional impact of all TUBA1A missense variants using experimental and computational methods, improving clinical variant classification.

Physiological Reconstitution of Microtubule Doublets

This study identifies FAP53 as a key factor in B-tubule assembly during microtubule doublet formation and shows its role in ciliogenesis across species.

Artificial Intelligence-Enabled AlphaFold II Pipeline Guides Functional Fluorescence Labeling of Tubulin Across Species

The paper develops an AI-driven method to label tubulin isotypes in vivo across species, enabling precise visualization of microtubule dynamics and pathogenic variants without disrupting cellular processes.

Spectrin-based Membrane Mechanics Is Asymmetric and Remodels during Neural Development

This study investigates the role of spectrin-based membrane mechanics in neuronal migration and dendrite formation in C. elegans, showing that spectrin's asymmetry and remodeling are critical for proper development.