GeneticsbioRxivPreprint
A CRISPR-engineered Isogenic Model Reveals Altered Neuronal Phenotypes of the 22q11.2 A-B Syndromic Deletion
Neha Paranjape, Yu-Hsiu Tony Lin, Quetzal Flores-Ramirez…·Arun P. Wiita
This study creates isogenic models of the 22q11.2 'A-B' deletion using CRISPR in iPS cells, revealing altered neuronal phenotypes through transcriptomic and proteomic analysis.