Mercedes F. Paredes

This study identifies branched-chain amino acid fermentation as an alternative electron sink in mammals under hypoxia, with implications for reductive stress and sperm motility.

This study maps the spatial and molecular changes in neural progenitor cells in the human dentate gyrus from gestation to postnatal stages, showing a decline in neurogenic potential and transition to astrocytic features.

This study creates a 3D multi-omic atlas of developing human basal ganglia and inhibitory neurons, revealing lineage-specific 3D genomic dynamics and regulatory programs associated with neuropsychiatric disease risk.

The paper analyzes the conservation and evolution of striatal interneurons across mammals, finding that TAC3 interneurons are conserved and that neuronal types evolve through redistribution and refinement.

This paper uses cerebral organoids to model Tuberous Sclerosis Complex and identifies mechanisms of neural activity changes in epileptogenesis, showing potential for drug testing.

The paper shows microglia regulate GABAergic neurogenesis in the prenatal human brain via IGF1, using single-cell transcriptomics and organoid models.

This study shows that the identity of MGE-derived cortical interneurons can be dynamically influenced by their environment, with human 3D models promoting Pvalb expression over Sst.

This study maps the molecular and cellular dynamics of the developing human neocortex using single-nucleus data, revealing gene regulatory networks and a cancer-related progenitor subtype.

The paper uses snRNA-seq to analyze mosaic chromosome 1q gain in a case of epilepsy with hyaline protoplasmic astrocytopathy, finding cell-type-specific gene expression changes in neurons and astrocytes.

The paper constructs a single-cell transcriptomic atlas of human cortical development, identifying lineage and sex-specific gene expression programs linked to autism risk.

This study creates a cross-species proteomic map of synapse development in human, macaque, and mouse neocortex, revealing slower human PSD maturation and its potential link to neoteny.

The paper identifies an expanded subventricular zone in neonatal gyrencephalic brains that supports ongoing neuronal migration to the cortex.

The paper investigates epigenomic and 3D chromatin conformation changes in human frontal cortex and hippocampus development using sn-m3C-seq, finding distinct chromatin conformations in neurons and glial cells and linking risk variants to regulatory regions.

This study creates isogenic models of the 22q11.2 'A-B' deletion using CRISPR in iPS cells, revealing altered neuronal phenotypes through transcriptomic and proteomic analysis.

This study uses cerebral organoids to show that TSC2 mutations cause over-proliferation of caudal late interneuron progenitors, leading to Tuberous Sclerosis Complex.

The paper identifies molecular subtypes of human interneuron progenitors and immature interneurons using single-cell RNA sequencing and compares them to mouse data, revealing species-specific gene programs.

This study shows that porcine embryonic medial ganglionic eminence progenitors develop into interneurons similar to rodents, supporting their use in xenotransplantation therapies.

The paper maps astrocyte layer diversity in the cortex using a high-content spatial transcriptomic pipeline, revealing distinct astrocyte identities and their relationship to neuronal organization.