Julia S. F. Chu

This study maps the spatial and molecular changes in neural progenitor cells in the human dentate gyrus from gestation to postnatal stages, showing a decline in neurogenic potential and transition to astrocytic features.

This paper uses cerebral organoids to model Tuberous Sclerosis Complex and identifies mechanisms of neural activity changes in epileptogenesis, showing potential for drug testing.

This study shows that the identity of MGE-derived cortical interneurons can be dynamically influenced by their environment, with human 3D models promoting Pvalb expression over Sst.

The paper identifies an expanded subventricular zone in neonatal gyrencephalic brains that supports ongoing neuronal migration to the cortex.

This study creates isogenic models of the 22q11.2 'A-B' deletion using CRISPR in iPS cells, revealing altered neuronal phenotypes through transcriptomic and proteomic analysis.

This study uses cerebral organoids to show that TSC2 mutations cause over-proliferation of caudal late interneuron progenitors, leading to Tuberous Sclerosis Complex.