Samuel J. Rozans

This paper develops and optimizes peptide crosslinks for hydrogels that are specifically degraded by membrane-type proteases, improving cell behavior compared to existing crosslinks.

This paper introduces a streamlined LC-MS assay for quantifying peptide degradation in cell culture without sample purification, enabling efficient assessment of peptide stability and functionality.

This study quantifies non-specific proteolytic degradation of cell adhesion peptides and shows that terminal modifications can reduce degradation in different cell types and matrices.