Abolfazl Salehi Moghaddam

Integrative Multiomic Analysis Reveals How Non-Viral Delivery System Selection Shapes CRISPR Gene Editing Outcomes in Stem Cells.

This study compares non-viral CRISPR delivery methods in stem cells, finding that lipid-based delivery offers high efficiency but risks genomic instability, while CPPs reduce side effects at lower efficiency.

Optimizing Peptide Crosslinks for Cell-Responsive Hydrogels

This paper develops and optimizes peptide crosslinks for hydrogels that are specifically degraded by membrane-type proteases, improving cell behavior compared to existing crosslinks.

Hydrogels with Independently Controlled Adhesion Ligand Mobility and Viscoelasticity Increase Cell Adhesion and Spreading

This paper designs a hydrogel platform with independently controllable adhesion ligand mobility and viscoelasticity, showing that dual presentation of RGD ligands on both covalent and dynamic networks maximizes endothelial cell adhesion and spreading.

A Streamlined High-Throughput LC-MS Assay for Quantifying Peptide Degradation in Cell Culture

This paper introduces a streamlined LC-MS assay for quantifying peptide degradation in cell culture without sample purification, enabling efficient assessment of peptide stability and functionality.

Quantifying and controlling the proteolytic degradation of cell adhesion peptides

This study quantifies non-specific proteolytic degradation of cell adhesion peptides and shows that terminal modifications can reduce degradation in different cell types and matrices.