E. Thomas Pashuck

This paper designs and synthesizes peptide-polyester conjugates that degrade in response to cell-mediated protease activity, enhancing tissue regeneration.

This paper develops and optimizes peptide crosslinks for hydrogels that are specifically degraded by membrane-type proteases, improving cell behavior compared to existing crosslinks.

This paper designs a hydrogel platform with independently controllable adhesion ligand mobility and viscoelasticity, showing that dual presentation of RGD ligands on both covalent and dynamic networks maximizes endothelial cell adhesion and spreading.

This paper introduces a streamlined LC-MS assay for quantifying peptide degradation in cell culture without sample purification, enabling efficient assessment of peptide stability and functionality.

This paper develops a high-swelling composite hydrogel, SwellMA, for 4D bioprinting, showing superior swelling capacity and on-demand swelling-shrinking behavior.

This study quantifies non-specific proteolytic degradation of cell adhesion peptides and shows that terminal modifications can reduce degradation in different cell types and matrices.