Molecular BiologybioRxivPreprint
Semaphorin 3A and 3F overexpression in TIE2 hyperactive endothelial cells contribute to the pathological lumen expansion in venous malformation
Sandra Schrenk, Chhiring Sherpa, Lindsay J. Bischoff…·Elisa Boscolo
This study shows that TIE2-mutant endothelial cells overexpress Semaphorin 3A and 3F, which repel wild-type endothelial cells and drive pathological lumen expansion in venous malformations.
DOI 10.1101/2025.07.18.665640