BiochemistryMolecular Biology and EvolutionPeer-reviewed
Adaptive capacity of a DNA polymerase clamp-loader ATPase complex
Subu Subramanian, Weilin Zhang, Siddharth Nimkar…·John Kuriyan
The paper shows that single point mutations can restore function to a defective DNA polymerase clamp-loader complex by compensating for reduced affinity between the clamp loader and the sliding clamp.
5 citations