Weilin Zhang

High temperature ligation enables in vitro assembly of eukaryotic genes

This paper introduces High Temperature (HighT) assembly, a DNA assembly method that improves accuracy and yield by ligating DNA at higher temperatures, and demonstrates its application in constructing synthetic genes and genomic regions.

Multiplexed construction of defined DNA products from unpartitioned oligonucleotide pools

The paper introduces a method for high-fidelity, multiplexed DNA construction from oligo pools, enabling efficient assembly of multiple defined constructs.

Rapid in vitro synthesis of DNA templates via Sidewinder for polyadenylated Hantavirus mRNA vaccine candidates

This study develops a rapid DNA template synthesis method called Sidewinder to produce polyadenylated Hantavirus mRNA vaccine candidates in just 2 days.

CellChem: Cellular transcriptional responses reshape molecular representation space for efficient and multi-scale drug discovery

CellChem learns cell-guided molecular representations that integrate structure and function, improving drug discovery by capturing cellular response similarities.

ANKRD5: a key component of the axoneme required for spermmotility and male fertility

This study identifies ANKRD5 as a critical component of the N-DRC in sperm axonemes, showing its role in maintaining structural integrity and motility, with implications for male fertility.