Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens
Daichao Wu, Rui Ming Yin, Guodong Chen, Helder Veras Ribeiro Filho, Melyssa Cheung, Paul F. Robbins, Roy A. Mariuzza, Brian G. Pierce
The paper determines crystal structures of a TCR complex with NRAS neoantigens and uses AlphaFold to model these complexes, showing varying success across different implementations.
Science Advances · Nov 22, 2024Peer-reviewedImmunology