Rui Ming Yin

This study evaluates AlphaFold's ability to model nanobody-peptide interactions, finding moderate success in some cases but limitations when translating to complex contexts.

This study engineers an HIV broadly neutralizing antibody to improve its potency, antiviral activity, and manufacturability while maintaining safety and efficacy.

The paper determines crystal structures of a TCR complex with NRAS neoantigens and uses AlphaFold to model these complexes, showing varying success across different implementations.

This study evaluates AlphaFold's performance in modeling antibody-antigen complexes, finding improved accuracy with a 30% success rate and identifying factors that enhance modeling success.

This study benchmarks AlphaFold for predicting protein complex structures, finding high accuracy for heterodimers but challenges for antibody-antigen complexes.

The paper shows that gene-specific homeostasis in C. elegans enables recovery from transgenerational RNA silencing, with silencing persisting for over 250 generations under certain conditions.