Author

Jake N Hermanson

Vanderbilt UniversityORCID 0009-0003-6891-1273Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Research Focus:software / tool· 1 Approach:statistical model· 1

Frequent Co-Authors

Lars PlateiD· 3 shared Lea A. BarnyiD· 2 shared Andrew D Hudson· 1 shared Philip E. StaufferiD· 1 shared Sarah K. Garcia· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 7 mutual co-author links

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3 shared papersSystems Biology

Lars PlateORCID

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3 papers

Recent·Most cited

BiochemistryJournal of Biological ChemistryPeer-reviewedJul 16, 2026

Public Cohort Analysis Identifies Thyroglobulin Variants as Hypothyroidism Risk Factors

Jake N Hermanson, Andrew D Hudson, Lars Plate

The paper identifies thyroglobulin variants associated with hypothyroidism risk using biobank data and molecular characterization, revealing distinct pathophysiological mechanisms for different variants.

DOI 10.1016/j.jbc.2026.113344

humanbulk RNA-seq

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Systems BiologyMolecular & Cellular ProteomicsPeer-reviewedJul 15, 2025

Dissecting Branch-Specific Unfolded Protein Response Activation in Drug-Tolerant BRAF-Mutant Melanoma using Data-Independent Acquisition Mass Spectrometry

Lea A. Barny, Jake N Hermanson, Sarah K. Garcia…·Lars Plate

This study identifies branch-specific UPR proteomic targets in BRAF-mutant melanoma using DIA LC-MS, revealing differential XBP1s regulation linked to drug tolerance.

7 citations

humanproteomics

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Systems BiologyJournal of Proteome ResearchPeer-reviewedMay 27, 2025

Development of an Adaptive, Economical, and Easy-to-Use SP3-TMT Automated Sample Preparation Workflow for Quantitative Proteomics

Jake N Hermanson, Lea A. Barny, Lars Plate

The paper develops an automated SP3-TMT sample preparation workflow for proteomics, showing it matches manual methods in performance while improving throughput, cost, and error reduction.

4 citations

proteomicsexperimental assay

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