NeurosciencebioRxivPreprint
Humanized TfR1 and transferrin gene-replacement rats for in vivo evaluation of BBB transport
Metin Yeşiltepe, Sanjay Kisan Metkar, Tao Yin…·Luciano D'adamio
This study develops humanized TfR1 and Tf gene-replacement rats to evaluate BBB transport of human-specific therapeutics, showing viability and partial functional compensation.
DOI 10.1101/2025.07.25.666792