Sanjay Kisan Metkar

This study shows that different polymorphs of lysozyme influence the structure and toxicity of cross-seeded insulin fibrils.

This study shows that structurally distinct amyloid polymorphs of HEWL have enhanced antibacterial activity compared to native HEWL, with flexible fibrils showing the strongest activity against multiple bacterial strains.

The paper develops NN-800s, trimeric nanobodies that inhibit TNFα and cross the BBB via TfR1, showing potent activity and safety in preclinical models.

This study develops humanized TfR1 and Tf gene-replacement rats to evaluate BBB transport of human-specific therapeutics, showing viability and partial functional compensation.

This paper develops humanized TfR1-targeting nanobodies (NewroBus) that cross the BBB and deliver therapeutic payloads to the CNS.