Luciano D'adamio

NN-800s: Brain-penetrant trimeric nanobodies enable potent TNFα inhibition via TfR1-mediated transcytosis

The paper develops NN-800s, trimeric nanobodies that inhibit TNFα and cross the BBB via TfR1, showing potent activity and safety in preclinical models.

Pathological Mechanisms of Motor Dysfunction in Familial Danish Dementia: Insights from a Knock-In Rat Model

This study uses a FDD-KI rat model to show that vascular amyloid deposition, neuroinflammation, and white matter damage contribute to motor dysfunction in Familial Danish Dementia.

Humanized TfR1 and transferrin gene-replacement rats for in vivo evaluation of BBB transport

This study develops humanized TfR1 and Tf gene-replacement rats to evaluate BBB transport of human-specific therapeutics, showing viability and partial functional compensation.

Development of potent humanized TNFα inhibitory nanobodies for therapeutic applications in TNFα-mediated diseases

This study develops and characterizes humanized TNFα inhibitory nanobodies with picomolar potency and low immunogenicity for therapeutic use in TNFα-mediated diseases.

NewroBus for the brain: humanized TfR1-targeting nanobodies with high BBB permeability and cargo transport capacity

This paper develops humanized TfR1-targeting nanobodies (NewroBus) that cross the BBB and deliver therapeutic payloads to the CNS.

BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer's disease and related dementias

The paper shows BRI2 regulates TREM2 processing in microglia, affecting Alzheimer's disease risk, and suggests BRI2 as a therapeutic target.

Initial assessment of the spatial learning, reversal, and sequencing task capabilities of knock-in rats with humanizing mutations in the Ass-coding region of App

The paper assesses spatial learning and sequencing task capabilities in knock-in rats with humanizing mutations in the App gene, finding they can learn basic tasks but not more complex ones.

Familial Danish dementia young Knock-in rats expressing humanized APP and human Aβ show impaired pre and postsynaptic glutamatergic transmission

The paper investigates early pathogenic changes in young rats with the Danish mutation in Itm2b, showing altered glutamatergic synaptic function and human Aβ levels.

Loss of CDC50A function drives Aβ/p3 production via increased β/α-secretase processing of APP

The paper shows that loss of CDC50A function increases β/α-secretase processing of APP, leading to higher Aβ and p3 production.

TNFα reduces inhibitory transmission in young Trem2R47H Sporadic Alzheimer rats before observable Aβ and brain pathology

The paper shows that the p.R47H TREM2 variant reduces GABAergic transmission in young Alzheimer rats, mediated by TNF-α, before Aβ accumulation and brain pathology.