Cancer BiologyMolecular TherapyPeer-reviewed
Tumor cell-derived lactic acid inhibits the interaction of PD-L1 protein and PD-L1 antibody in the PD-L1/PD-1 blockade therapy-resistant tumor
Wonkyung Oh, Alyssa Min Jung Kim, Deepika Dhawan…·Seung‐Oe Lim
This study identifies tumor-derived lactic acid as a factor inhibiting PD-L1 antibody binding, contributing to PD-1/PD-L1 blockade resistance, and proposes a combination therapy to overcome this resistance.
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