Jessica James

This paper introduces SLIDE, a method to estimate landscape ruggedness in directed evolution using population-level phenotypic data and mutation rate, improving selection strategies for protein design.

This paper introduces engineered magneto-sensitive fluorescent proteins that enable quantum sensing in living cells through optically detected magnetic resonance.

This paper introduces MiPS, a microfluidic platform for automated single-cell selection based on dynamic, multi-trait phenotypes using real-time imaging and optical targeting.

This paper introduces SIMPLIFE, a computational workflow for designing optimal insertion sites for conjugation tags in proteins, demonstrating its use in augmenting T7 RNA polymerase function.

This paper develops selection strategies for directed evolution without sequencing, showing they can increase the probability of finding the global fitness peak by up to 7.5 fold.