Sebastian Towers

This paper introduces SLIDE, a method to estimate landscape ruggedness in directed evolution using population-level phenotypic data and mutation rate, improving selection strategies for protein design.

This paper introduces MiPS, a microfluidic platform for automated single-cell selection based on dynamic, multi-trait phenotypes using real-time imaging and optical targeting.

This paper develops selection strategies for directed evolution without sequencing, showing they can increase the probability of finding the global fitness peak by up to 7.5 fold.